Publications
1. Borquez JC, Diaz-Castro F, La Fuente FP, Espinoza K, Figueroa AM, Martinez-Ruiz I, Hernandez V, Lopez-Soldado I, Ventura R, Domingo JC, Bosch M, Fajardo A, Sebastian D, Espinosa A, Pol A, Zorzano A, Cortes V, Hernandez-Alvarez MI and Troncoso R (2024) Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD. Metabolism 152:155765. doi: 10.1016/j.metabol.2023.155765.
https://www.metabolismjournal.com/article/S0026-0495(23)00369-4/abstract
2. Déborah Naón , María Isabel Hernández-Alvarez , Satoko Shinjo , Milosz Wieczor, Saska Ivanova , Olga Martins de Brito , Albert Quintana , Juan Hidalgo , Manuel Palacín , Pilar Aparicio , Juan Castellanos , Luis Lores, David Sebastián , Sonia Fernández-Veledo , Joan Vendrell , Jorge Joven , Modesto Orozco , Antonio Zorzano , Luca Scorrano. Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria. Science 2023 Jun 23;380(6651)
3. Marc Leiro, Raúl Ventura, Nil Rojo-Querol, María Isabel Hernández-Alvarez. Endoplasmic Reticulum Isolation: An Optimized Approach into Cells and Mouse Liver Fractionation. Bio-protocol Journal Vol 13, Iss 17, Sep 5, 2023
https://cn.bio-protocol.org/en/bpdetail?id=4803&type=0
4. Lopez-Soldado I, Torres AG, Ventura R, Martinez-Ruiz I, Diaz-Ramos A, Planet E, Cooper D,Pazderska A, Wanic K, O’Hanlon D, et al. Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle. Redox Biol. 2023;61(102630.
https://www.sciencedirect.com/science/article/pii/S2213231723000319?via%3Dihub
5. Ventura R, Martinez-Ruiz I, and Hernandez-Alvarez MI. Phospholipid Membrane Transport and Associated Diseases. Biomedicines. 2022;10(5).
https://www.mdpi.com/2227-9059/10/5/1201
6. Hernandez-Alvarez MI, and Zorzano A. Mitochondrial Dynamics and Liver Cancer. Cancers (Basel). 2021;13(11).
https://www.mdpi.com/2072-6694/13/11/2571
7. Lopez-Soldado I, Guinovart JJ, and Duran J. Increased liver glycogen levels enhance exercise capacity in mice. J Biol Chem. 2021;297(2):100976.
https://www.jbc.org/article/S0021-9258(21)00778-X/fulltext
8. Cisa-Wieczorek S, and Hernandez-Alvarez MI. Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases. Cells. 2020;9(12).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761975/
9. Hernandez-Alvarez MI, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernandez V, Vasconcelos N, et al. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell. 2019;177(4):881-95 e17.
https://www.cell.com/cell/fulltext/S0092-8674(19)30396-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS00
92867419303964%3Fshowall%3Dtrue
10. Keiran N, Ceperuelo-Mallafre V, Calvo E, Hernandez-Alvarez MI, Ejarque M,
Nunez-Roa C, Horrillo D, Maymo-Masip E, Rodriguez MM, Fradera R, et al. SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Nat Immunol. 2019;20(5):581-92.
https://www.nature.com/articles/s41590-019-0372-7
11. Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P,
Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, et al. Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J. 2019;38(10).
https://www.embopress.org/doi/full/10.15252/embj.201899300
12. Veiga SR, Ge X, Mercer CA, Hernandez-Alvarez MI, Thomas HE, Hernandez-Losa J, Ramon YCS, Zorzano A, Thomas G, and Kozma SC. Phenformin-Induced
Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR. Clin Cancer Res. 2018;24(15):3767-80.
13. Hernandez-Alvarez MI, Diaz-Ramos A, Berdasco M, Cobb J, Planet E, Cooper D, Pazderska A, Wanic K, O’Hanlon D, Gomez A, et al. Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism. Sci Rep. 2017;7(1):13850.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653857/
14. Maillo C, Martin J, Sebastian D, Hernandez-Alvarez M, Garcia-Rocha M, Reina O, Zorzano A, Fernandez M, and Mendez R. Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. Nat Cell Biol. 2017;19(2):94-105.
https://www.nature.com/articles/ncb3461
15. Lopez-Soldado I, Fuentes-Romero R, Duran J, and Guinovart JJ. Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice. Diabetologia. 2017;60(6):1076-83.
https://link.springer.com/article/10.1007/s00125-017-4240-4
16. Lopez-Soldado I, Zafra D, Duran J, Adrover A, Calbo J, and Guinovart JJ. Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model. Diabetes. 2015;64(3):796-807.
https://diabetesjournals.org/diabetes/article/64/3/796/40338/Liver-Glycogen-Reduces-Food-Intake-and-Attenuates
17. Hernandez-Alvarez MI, Paz JC, Sebastian D, Munoz JP, Liesa M, Segales J, Palacin M, and Zorzano A. Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1. Antioxid Redox Signal. 2013;19(4):366-78.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700019/
18. Sebastian D, Hernandez-Alvarez MI, Segales J, Sorianello E, Munoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, et al. Mitofusin 2 (Mfn2) links
mitochondrial and endoplasmic reticulum function with insulin signaling and is
essential for normal glucose homeostasis. Proc Natl Acad Sci U S A.
2012;109(14):5523-8.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325712/
19. Hernandez-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, et al. Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1alpha/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care. 2010;33(3):645-51.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827524/pdf/zdc645.pdf
Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease
Juan Carlos Bórquez, Francisco Díaz-Castro, Francisco Pino-de La Fuente, Karla
Espinoza, Ana María Figueroa, Inma Martínez-Ruíz, Vanessa Hernández, Iliana López-Soldado, Raúl Ventura, Alejandra Espinosa, Víctor Cortés, María Isabel Hernández-Alvarez, Rodrigo Troncoso
https://www.biorxiv.org/content/10.1101/2023.01.31.526481v1
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes
downregulation of mitochondrial OXPHOS subunits in type 2 diabetic skeletal muscle.
Iliana López-Soldado, Adrian Gabriel Torres, Raúl Ventura, Inma Martínez-Ruiz,
Angels Díaz-Ramos, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzysztof
Wanic, Declan O’Hanlon, Donal J. O’Gorman, Teresa Carbonell, Lluís Ribas de
Pouplana, John J. Nolan, María Isabel Hernández-Alvarez.
https://www.medrxiv.org/content/10.1101/2022.12.30.22283970v1